Scientists have reportedly developed a "fentanyl vaccine" to block the drug's effects on the brain. The hosts sign off with a reminder of the "value-for-value" model and play the "End of Show Mixes" by Mattie J and Fletcher Trap Dog.
14 chapters across the catalog
Scientists have reportedly developed a "fentanyl vaccine" to block the drug's effects on the brain. The hosts sign off with a reminder of the "value-for-value" model and play the "End of Show Mixes" by Mattie J and Fletcher Trap Dog.
The episode concludes with a musical mix featuring a parody of Johnny Paycheck's "Take This Job and Shove It," retitled "Take This Jab and Shove It." The lyrics criticize vaccine mandates, the speed of Pfizer's development, and political hypocrisy. The hosts sign off with their traditional "Adios Mofos" as the show transitions to the Lotus Podcast.
The hosts urge artists to update their profiles on the No Agenda Art Generator. They review potential "In Search Of" (ISO) clips for the end of the show, including a child's comment about loving being vaccinated.
The episode concludes with a series of audio mixes, including the "No Agenda Alphabet" by Sir Chris from Australia. The hosts sign off from Texas and Silicon Valley, reminding listeners to return for the next deconstruction on Sunday.

Buddy Arsenault, Rolando Gonzalez, Baron Gordon Walton
Buddy Arsenault, an oilfield service worker facing a vaccine mandate, is acknowledged alongside long-time producers Rolando Gonzalez and Baron Gordon Walton. Walton has reportedly attended every No Agenda meetup since the show's inception.
Top FDA officials have resigned amid disagreements over the government's push for boosters, suggesting a rift between political goals and scientific advisory boards. Dr. Anthony Fauci addressed questions regarding the safety of mixing different vaccine brands for booster shots, stating the practice is still under study.
The episode concludes with a clip of President Joe Biden mistakenly using the word "vaxation" and claiming that 350 million Americans have been vaccinated. The hosts mock the statistical impossibility of the claim and the linguistic error. The show signs off with the traditional "Adios, mofos" and an end-of-show music mix featuring various show clips and themes.

J&J Vaccine Supplemental Shots and San Francisco Top-Offs
CBS News issued a warning from doctors advising Johnson & Johnson vaccine recipients against taking supplemental "top-off" shots. This contradicts reports from San Francisco where local health officials have encouraged residents to get a Pfizer booster following their initial J&J dose. The shift marks a reversal from 2020 guidance which strictly prohibited mixing different vaccine brands.
Dr. Vin Gupta suggested on television that individuals who received the single-dose Johnson & Johnson vaccine should "top off" with a dose of Pfizer or Moderna. This marks a significant shift from earlier medical guidance that strictly prohibited mixing different vaccine technologies. Critics argue this advice is being given without clinical trial data and treats medical procedures like a "gas tank."

Vaccine Mixing, Top-Off Strategy, Public Health Messaging
Public health discussions have shifted toward the possibility of "topping off" or mixing different vaccine brands, such as following a Johnson & Johnson shot with a Pfizer booster. This contradicts earlier guidance that strictly prohibited mixing different vaccine types. The change in messaging has led to confusion regarding the long-term efficacy of the initial vaccination series.
New reports suggest that mixing different COVID-19 vaccines, such as following a Johnson & Johnson shot with a Pfizer booster, may be effective. The hosts highlight the reversal in medical advice, noting that mixing was previously strictly forbidden.
New guidance suggests that different vaccine brands, such as Pfizer and Moderna, may be mixed if necessary. While the Johnson & Johnson vaccine has a lower overall efficacy rate (66%) compared to Pfizer and Moderna (95%), it is 85% effective at preventing severe disease and hospitalization. Health officials encourage taking any available vaccine to prevent death, even if it does not provide full immunity.
The show ends with a critique of a PBS montage featuring Americans expressing a desperate desire for the COVID-19 vaccine, which the hosts characterize as manufactured demand. Final credits are given to the "Thought Doc" for the end-of-show mix. The hosts sign off from Austin and Silicon Valley, promising to return on Thursday to "punch through the bullcrap."
The program concludes with a musical mix featuring themes of lockdown defiance and "creative stats." Audio clips include Dr. Anthony Fauci discussing the challenges of achieving herd immunity through a vaccine and Joe Biden's "you ain't black" comment. The final segments reiterate Kanye West's presidential ambitions and the general "anti-science" sentiment in the country.