Topic: Show 600

The hosts reflect on the history of the program, specifically recalling Show 100 when one host considered quitting during a divorce. They discuss when the show truly "hit its stride," mentioning Show 381 (The Pipeline Show) and Show 600 as significant milestones in their deconstruction style.

Xeni Jardin of Boing Boing appeared on the News Hour to discuss how social media is changing human interaction. The hosts mock the academic language used to describe these changes, such as "design limitations." The episode concludes with a reminder of the upcoming 600th show on Sunday.

Adam Curry and John C. Dvorak open episode 597 of the No Agenda show from Austin, Texas, and Northern Silicon Valley. They calculate the timeline for their upcoming 600th episode, noting it coincides with the Ides of March and their six-week production cycle.

As they approach their 600th episode, the hosts begin discussing Zohydro, a powerful new painkiller approved by the FDA. They note the media coverage of the drug's potency and the public health concerns surrounding its release.

The hosts sign off from Austin and Silicon Valley, previewing their next show on Sunday. They remind listeners to visit their website for "unfettered" information and conclude with a satirical Joe Biden audio clip.

The hosts read a second round of donations, including a contribution from "Rain Stick Goddess" Sherry Draper. They grant "de-douching" and relationship karma to various listeners. They remind the audience of the upcoming 600th episode and the "Special Executive Producer" club for that milestone.