Topic: Sylvia Mathews Burwell

Peggy Brittan is officially knighted as "Dame Ya Know" with a custom list of "hookers and blow" style requests. The hosts then discuss Sylvia Mathews Burwell, the Secretary of Health and Human Services. They review her professional background at the Walmart Foundation and the Bill & Melinda Gates Foundation, noting her influence in global development.

Secretary Sylvia Mathews Burwell testifies about the opioid epidemic, noting that overdose deaths now exceed car accident fatalities. She reveals that 259 million opioid prescriptions were written in 2012, nearly one for every adult in the U.S. The hosts mock her use of corporate jargon like "solution space" and "prescribing space" during her testimony.